Weight Loss with Peptides

Struggling with weight loss despite dieting and exercise? At Longitude Health, we offer cutting-edge medical weight loss solutions with Semaglutide and Tirzepatide — two of the most effective medications available for sustainable weight management. Our at-home service brings expert care and proven treatments directly to you, making it easier than ever to achieve your weight loss goals.

Traditional weight loss methods often fail because they don’t address the underlying metabolic and hormonal imbalances that contribute to weight gain. Crash diets, extreme exercise, and calorie restriction can lead to temporary weight loss followed by rapid regain.

Our medical weight loss program targets the root causes of weight gain — including insulin resistance, appetite dysregulation, and slow metabolism — using clinically proven medications and personalized care.

How It Works

Initial Consultation

Our medical team conducts a comprehensive health assessment, including metabolic health, hormonal balance, and lifestyle factors.

Personalized Plan

Based on your health profile, we create a customized weight loss plan that includes medication, nutrition guidance, and lifestyle recommendations.

At-Home Convenience

Medications are administered in the comfort of your home by our licensed nurses, and our medical team is available for virtual consultations and support.

Ongoing Support

Regular follow-ups and lab testing ensure that your treatment is safe and effective, with adjustments made as needed.

Semaglutide for Weight Loss

Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist originally developed to treat type 2 diabetes. It works by mimicking the effects of GLP-1, a hormone that regulates appetite and blood sugar levels.

Mechanism of Action:

Increases insulin secretion in response to meals
Delays gastric emptying, making you feel fuller longer
Reduces appetite by acting on the brain’s hunger centers
Lowers blood glucose levels and improves insulin sensitivity

Benefits of Semaglutide:

✅ Significant weight loss (average of 12%–15% of body weight)

✅ Reduced appetite and fewer food cravings

✅ Improved blood sugar control

✅ Enhanced cardiovascular health and reduced inflammation

✅ Lower risk of metabolic syndrome and type 2 diabetes

Clinical Evidence:

📖 A 2021 study in The New England Journal of Medicine found that adults taking Semaglutide lost an average of 14.9% of their body weight over 68 weeks compared to 2.4% in the placebo group. (Source)

📖 A 2022 trial published in JAMA showed that Semaglutide improved metabolic markers, including fasting glucose and triglyceride levels, in overweight adults. (Source)

📖 Research in Diabetes, Obesity and Metabolism confirmed that Semaglutide reduces visceral fat and improves body composition. (Source)

Tirzepatide for Weight Loss

Tirzepatide is a dual GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptor agonist. This means it targets two key metabolic pathways, making it even more effective for weight loss and blood sugar regulation.

Mechanism of Action:

Activates both GLP-1 and GIP receptors to enhance insulin secretion and improve glucose metabolism
Slows gastric emptying, increasing feelings of fullness
Reduces appetite and food intake through direct action on the hypothalamus
Promotes fat loss while preserving lean muscle mass

Benefits of Tirzepatide:

✅ Superior weight loss (average of 15%–22% of body weight)

✅ Improved insulin sensitivity and glucose control

✅ Enhanced fat metabolism and reduced visceral fat

✅ Increased satiety and reduced hunger

✅ Improved cardiovascular health markers

Clinical Evidence:

📖 A 2022 study in The New England Journal of Medicine reported that adults taking Tirzepatide lost an average of 21% of body weight over 72 weeks — the highest weight loss ever recorded in a clinical trial for obesity medication. (Source)

📖 A 2023 trial in The Lancet confirmed that Tirzepatide improves body composition by reducing fat mass while maintaining muscle mass. (Source)

📖 Research in Diabetes Care showed that Tirzepatide significantly lowers A1C levels and reduces cardiovascular risk factors. (Source)

How Semaglutide and Tirzepatide Compare

	Semaglutide	Tirzepatide
Mechanism	GLP-1 receptor agonist	GLP-1 + GIP receptor agonist
Average Weight Loss	12%–15% of body weight	15%–22% of body weight
Frequency	Weekly injection	Weekly injection
Appetite Reduction	Significant	More pronounced
Metabolic Impact	Improves glucose metabolism and insulin sensitivity	Stronger effect on glucose and fat metabolism
Side Effects	Nausea, vomiting, mild GI discomfort	Nausea, vomiting, fatigue, mild GI discomfort

Who is a Good Candidate for Medical Weight Loss?

Medical weight loss with Semaglutide or Tirzepatide may be ideal if you:

✅ Have a BMI of 27 or higher with weight-related health issues (e.g., high blood pressure, insulin resistance)

✅ Struggle with emotional or binge eating

✅ Experience metabolic slowdown despite regular exercise and dieting

✅ Have tried other weight loss methods without success

✅ Want to improve overall metabolic health and body composition

FAQs

Q: How long does it take to see results?

A: Most patients begin to notice reduced appetite and initial weight loss within the first 2–4 weeks. Maximum benefits typically appear within 12–24 weeks.

Q: Are there side effects?

A: Common side effects include mild nausea, fatigue, and occasional digestive discomfort. These symptoms usually resolve after a few weeks.

Q: Is it safe to take Semaglutide or Tirzepatide long-term?

A: Long-term studies have shown that both medications are safe when used under medical supervision. Regular monitoring ensures that any side effects are managed appropriately.

Q: What happens if I stop taking the medication?

A: Without lifestyle adjustments, some weight regain may occur after stopping treatment. Our team will help you develop a sustainable maintenance plan to preserve your results.